APT IMAGING OF HEPATOCELLULAR CARCINOMA SIGNALS AN EFFECTIVE THERAPEUTIC RESPONSE IN ADVANCE OF TUMOR SHRINKAGE

APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage

Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showe

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New early Pliocene owls from Langebaanweg, South Africa, with first evidence of Athene south of the Sahara and a new species of Tyto

The fossiliferous Upper Varswater Formation at Langebaanweg (South Africa) produced remains of at least five species of owls (Strigiformes).Tyto richae sp.nov.is the first palaeospecies of Tytonidae described from an African fossil site, though indeterminate remains referable to the genus Tyto are known from the Middle Miocene of Morocco, the early

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